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Immune Therapy A Great Tool, But Limitations Exist

Immune Therapy A Great Tool, But Limitations Exist

News free up, American Society of Clinical Oncology.


The ASCO Post: “AACR 2016: Five-Year Survival Rates for Patients With Metastatic Melanoma Treated With Nivolumab Much Higher Than Historical Rates.”


Cancer Research Institute: “Timeline of Progress.”

News free up, National Cancer Institute.


International Journal of Molecular Sciences: “Emerging Role of Immune Checkpoint Blockade in Pancreatic Cancer.”


Frontiers in Oncology: “Immune Checkpoints and Innovative Therapies in Glioblastoma.”


NEJM Journal Watch: “Microsatellite Instability in Prostate Cancer and the Role of Immune Checkpoint Blockade.”

News free up, FDA.

Reuters: “Merck’s Keytruda fails as monotherapy in breast most cancers learn about.”

OncologyPRO: “Overall survival at 4 years of follow-up in a phase 3 trial of nivolumab plus ipilimumab combination therapy in advanced melanoma (CheckMate 067).”

Medscape: “Cancer Drugs Dominate Top 10 Best-Selling Drugs in 2018.”


American Health & Drug Benefits: “Treating with Checkpoint Inhibitors — Figure $1 Million per Patient.”

Allison Betof Warner, MD, PhD, oncology fellow; melanoma school member (as of July 1), Memorial Sloan Kettering Cancer, New York City.

Mark Awad, MD, PhD, medical director, Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston; assistant professor, Harvard Medical School, Boston.

Drew Pardoll, MD, PhD, director, Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins Medicine, Baltimore; Abeloff professor of oncology, drugs, pathology and molecular biology and genetics, Johns Hopkins University School of Medicine, Baltimore.

Padmanee Sharma, MD, PhD, professor, Department of Genitourinary Medical Oncology, Division of Cancer Medicine, University of Texas MD Anderson Cancer Center, Houston; professor, Department of Immunology, Division of Cancer Medicine, University of Texas MD Anderson Cancer Center, Houston.

Keith Flaherty, MD, professor of drugs, Harvard Medical School, Boston; director, Henri and Belinda Termeer Center for Targeted Therapy, Cancer Center, Massachusetts General Hospital, Boston; director, medical analysis, Cancer Center, Massachusetts General Hospital, Boston.

DISCLOSURES:

Pardoll has gained grants from Bristol-Myers-Squibb and Melanoma Research Alliance; and private charges from Five Prime Therapeutics, Aduro, Compugen, GlaxoSmithKline, Medimmune/AstraZeneca, Merck, Potenza Therapeutics, Sanofi, Tizona, DNatrix, Amgen, Rock Springs Capital, Immunomic Therapeutics, Janssen, Astellas, WindMill Therapeutics, and Bayer. Flaherty serves at the forums of administrators of Clovis Oncology, Strata Oncology, Vivid Biosciences, Checkmate Pharmaceuticals, the company advisory forums of X4 Pharmaceuticals, PIC Therapeutics, the medical advisory forums of Sanofi, Amgen, Asana, Adaptimmune, Fount , Aeglea, Array BioPharma, Shattuck Labs, Tolero, Apricity , Oncoceutics , Fog Pharma , Neon, and Tvardi l He is a specialist for Novartis, Genentech, BMS, Merck, Takeda, Verastem, Boston Biomedical, Pierre Fabre, Cell Medica, and Debiopharm. Sharma owns a patent approved to Jounce Therapeutics. She serves as a specialist for Constellation, Jounce, Neon, BioAtla, Pieris, Oncolytics, Merck, Forty-Seven, Polaris, Apricity, Marker Therapeutics, Codiak, ImaginAb, Hummingbird, Dragonfly, Lytix. 

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